The Methods of Medication Discovery Nowadays

The twenty first century has opened new possibilities in the sphere of medication research and development but it is still really expensive procedure. The usual total cost per drug research varies from 897 million of US dollars to 1.9 billion of US dollars. Chemists need approximately 15 years to discover all the peculiar characteristics of this or that drug. At first in the research process scientists are to find a target (e.g. protein) and than take various medications that can interreact with this target. Then come clinical experiments that are the costliest and important part of the development because it needs to get a lot of bureaucratic approvals. In the US drugs must be approved by the Food and Drug Administration (FDA). So, drug discovery process is costly and arduous procedure that needs a lot of efforts.

The best way of identification good medical candidate is investigation of the interaction of target protein with various compounds that are selected by chemists from special compound lists where these compounds are kept. This testing is often done in so called high-throughput screening (HTS) facilities. Compound libraries are commercially available in sizes of up to several thousands of compounds. The most challenging exemplars obtained from the screening are called hits - these are the exemplars that show binding activity towards the target. After that some hits are taken to lead compounds. In future they will be refined and transformed to have greater outcome from their interaction and less side-effects.

You can see several various ways of drug design & discovery nowadays. There are given several modes of discovering drug candidate and you can find their pros and cons:

1. Virtual screening (VS) is the first method that means the discovery of virtually created medication and its interaction similar to reality;

This method has such advantages:

- it is cheap because it doesn’t need any costs for scientists who will create compounds;

- chemists can investigate various compounds that are yet in project;

- HTS is really costly and VS gives an opportunity to select a number of helpful compounds for further HTS experiments;

- great amount of elements to look from.

Also virtual screening presents really great number of elements that may be utilized in investigation than high-throughput screening gives to scientists. But we are to say about the disadvantage of virtual screening. That is inability to observe real interaction of compounds.

2. HTS is a real screening and it may use a large number of compounds per day. This method shows genuine results that are utilized for medication discovery. But it needs huge costs.

Computing means can be utilized to forecast or simulate how a specific compound reacts with a given protein target. It is done for defining the results and chemical features of medication designing and future features of the medication as a medicine. Molecular Docking, Quantitative Structure-Activity Relationships (QSAR) and Pharmacopoeia Mapping are the means that are utilized nowadays in nowadays drug discovery process. If you would like to have drug discovery service you may order it on our source.

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